Jason Carlyon, Ph.D.
Microbiology and Immunology
Virginia Commonwealth University School of Medicine, Richmond, Virginia

“Pathogen as Cell Biologist: Infection Strategies of Tick-Transmitted Bacterium, Anaplasma phagocytophilum”

Evolution at the host-microbe interface has selected for obligate intracellular bacteria to act as
“master cell biologists” that co-opt/modulate eukaryotic cellular processes to their advantage.
Understanding the mechanisms by which these pathogens invade, propagate within, and
disseminate from host cells could yield new targets for preventing or treating infectious disease. Anaplasma phagocytophilum is a tick-transmitted obligate intracellular bacterium that causes granulocytic anaplasmosis, a potentially severe infection of humans and some domestic animals. Treatment options for this globally emerging health threat are limited, and no vaccine exists. Its lifestyle as an obligate endosymbiont that infects neutrophils to complete its enzootic cycle engenders A. phagocytophilum success as a pathogen when vectored to accidental human and other non-reservoir hosts. This lecture will describe how A. phagocytophilum uses multiple adhesins to facilitate entry and how interfering with one or more of these interactions impairs infection. The A. phagocytophilum vacuole (ApV) is a hub that acquires vesicular traffic from numerous organelle sources to drive its intracellular parasitism and infectious progeny production. The lecture will also mechanistically explain how the ApV promiscuously interacts with multiple membrane trafficking pathways as well as how this strategy can be targeted to impede different infection cycle stages. Overall, this talk will review insights into A. phagocytophilum molecular pathogenesis and potential targets for therapeutic intervention.

NEW LOCATION: Papadakis Integrated Sciences Building (PISB), Drexel University Campus in University City, 3245 Chestnut Street (33rd and Chestnut), Philadelphia 19104

Reception (free): 5pm

Lecture: 6 – 7pm

Parking: Drexel University Parking Garage, 34th Street between Chestnut and Market Streets, entrance is on 34th and Ludlow), Philadelphia, PA 19104. Parking validation will be provided if using this garage at a cost of $5.00.

Septa Subways and Trolleys: The Market-Frankford Line (the Blue Line) stops at 30th and 34th streets, and all trolley trains (the Green Lines) stop at 30th and 33rd streets. Directions to PISB are below. 

  • From 30th Street Station to Papadakis Integrated Sciences Building (PISB): Walk one block south to Chestnut Street. Follow Chestnut Street west, passing under a train bridge, to the Papadakis Integrated Sciences Building (PISB) located on the northeast corner of 33rd and Chestnut streets.
  • From 33rd or 34th Street and Market Street to PISB: Walk one block south to Chestnut Street. Proceed east on Chestnut Street. The Papadakis Integrated Sciences Building is located on the northeast corner of 33rd and Chestnut streets. 

Meeting Recording: For those individuals who cannot make it to the meeting, we will live stream the meeting either by Zoom (see branch email) or our Branch YouTube Channel, https://www.youtube.com/@epaasm/streams

“What’s New in 2022: Clinical Microbiology Update”

Friday, November 11, 2022
Thomas Jefferson University, Jefferson Alumni Hall
1020 Locust Street
Philadelphia 19107

Register Here – Registration

Early Registration
$50 members
$75 non-members
After November 4
$75 members
$100 non-members

Quantifying Clean: Role of Surfaces in Healthcare-Associated Infection

Matthew Ziegler, MD, MSCE

Assistant Professor of Medicine and Epidemiology

University of Pennsylvania

Dr. Ziegler is an Assistant Professor of Medicine in the Division of Infectious Diseases, Department of Medicine, Assistant Professor of Epidemiology in the Department of Biostatistics Epidemiology and Informatics (DBEI), Senior Scholar at the Center for Clinical Epidemiology and Biostatistics (CCEB) at the University of Pennsylvania, and an Associate Medical Director of Healthcare Epidemiology, Infection Prevention and Control at the Hospital of the University of Pennsylvania. His clinical research program focuses on the prevention of healthcare-associated infections in immunocompromised patients and the epidemiology of multidrug-resistant organisms (MDROs) within the hospital built environment. His research is supported by the National Institute of Allergy and Infectious Diseases (NIAID) and the Centers for Disease Prevention and Control Prevention Epicenters program. His presentation will focus on the role of surfaces in the healthcare environment, specifically how bacteria are shared between patients and surfaces and how improved environmental cleaning may prevent healthcare-associated infection.

Eakins Lounge
Thomas Jefferson Alumni Hall First Floor
1020 Locust Street, Philadelphia

Watch the recorded meeting on our YouTube Channel

Please join us for this special monthly meeting in honor of former Branch President and long-standing Branch Member, James A. Poupard, Ph.D.

5 – 6:00 pm: Reception & Light Supper
6 – 6:15 pm: Brief highlights of Dr. Poupard’s career and work for the Branch, Linda A. Miller, Ph.D.
6:15 – 6:30 pm: Dr. Poupard’s work with the ASM Center for the HIstory of Microbiology (CHOMA), Toby K. Eisenstein, Ph.D.
6:30 – 7:00 pm: Keynote Lecture, “How do you know how to treat an infection? Recent updates in antimicrobial susceptibility testing”, Matthew A. Pettengill, Ph.D., D(ABMM), Department of Pathology, Anatomy, and Cell Biology, Director, Clinical Microbiology, Thomas Jefferson University, Philadelphia

Location: Thomas Jefferson University Alumni Hall, Eakins Lounge, First Floor
1020 Locust Street

Watch the program on our YouTube Channelclick here

Link to Obituary for James Poupard