Manuela Raffatellu, MD
Professor, Department of Pediatrics
University of California San Diego

“Nutritional Immunity in the Inflamed Gut”

In response to infection with enteric pathogens that cause inflammatory diarrhea, such as Salmonella Typhimurium, the host mounts a response termed nutritional immunity, which limits the availability of essential metal ions including iron, zinc, and manganese. This lecture will discuss the host cytokines that regulate nutritional immunity, and will outline the roles of two antimicrobial proteins, lipocalin-2 and calprotectin, in sequestering metal ions during colitis and their effects on gut pathogens and on the gut microbiome. 

5pm, free reception
6pm, seminar

Thomas Jefferson University
Bluemle Life Sciences Building
233 S. 10th Street (10th an Locust), Philadelphia 19104

Discounted parking at the garage on 11th and Locust (entrance on 11th Street under the Hamilton Bldg)