Matthias Machner, PhD
Senior Investigator, Section of Microbial Pathogenesis, NIH (NICHD/DIR)

“How to poke the Hippo – insight into a novelLegionella effector kinase”

Dr. Machner’s main research goal is to obtain mechanistic insight into the virulence strategies of microbial pathogens. As a model organism his laboratory uses the bacterium Legionella pneumophila, the causative agent of a potentially fatal respiratory infection known as Legionnaires’ disease. Contrary to what its name may imply, Legionnaires’ disease occurs in individuals of all ages, including children who receive respiratory therapy, newborns who recently underwent surgery or under-water birth, and children who are immunecompromised.  Dr. Machner’s team is committed to the in-depth analysis of mechanisms that allow L. pneumophila to exploit the human host and cause disease. Insights gained from these studies will ultimately improve our ability to better diagnose, prevent, and fight Legionnaires’ disease and related illnesses, thereby contributing to the success of NICHD’s mission.

Dr. Machner’s Lab Website:

Free reception:  5:00 pm
Seminar:  6:00 – 7:00 pm

Thomas Jefferson University,  Bluemle Life Sciences Bldg, Rm 101
233 S. 10th Street (10th and Locust)

Discounted parking at the garage on 11th and Locust (entrance on 11th street under the Hamilton Bldg)